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Beyond transcriptional silencing via DNA methylation, post-transcriptional RNA modifications are emerging as an equally pivotal layer of epigenetic regulation

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9), and from in vivo ischaemia in the brain using the middle cerebral aretery occlusion (MCAO) model (Supplementary Fig

This methylation reaction serves important regulatory functions but also depletes NAD+ by converting it to compounds that cannot participate in NAD+-dependent metabolism